Vaccine Spike vs. SARS-COV-2 Spike <br /> <br />There has been a lot of discussion for the spike and ACE2 binding. I have recorded many talks on this topic as well. However, an important piece missing for us has been to understand the difference of the spike between the vaccine and the virus. Let's review these differences. <br /> <br />If you like this content and want more, I am doing a special one-time membership offer. 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The content provided in this video is for informational and educational purposes only. <br />Please consult with a physician or healthcare professional regarding any medical or mental health related diagnosis or treatment. No information in this video should ever be considered as a substitute for advice from a healthcare professional. <br /> <br /> <br />URL list from Thursday, Nov. 17 2022 <br /> <br />DrBeen: Medical Education Online <br /><a href="https://www.drbeen.com/" target="_blank" rel="nofollow">https://www.drbeen.com/</a> <br /> <br />SARS-CoV-2 spike protein: pathogenesis, vaccines, and potential therapies | SpringerLink <br /><a href="https://link.springer.com/article/10.1007/s15010-021-01677-8" target="_blank" rel="nofollow">https://link.springer.com/article/10.1007/s15010-021-01677-8</a> <br /> <br />SARS-CoV-2 structural features may explain limited neutralizing-antibody responses | npj Vaccines <br /><a href="https://www.nature.com/articles/s41541-020-00264-6" target="_blank" rel="nofollow">https://www.nature.com/articles/s41541-020-00264-6</a> <br /> <br />SARS-CoV-2 spike behavior in situ: a Cryo-EM images for a better understanding of the COVID-19 pandemic | Signal Transduction and Targeted Therapy <br /><a href="https://www.nature.com/articles/s41392-020-00365-7" target="_blank" rel="nofollow">https://www.nature.com/articles/s41392-020-00365-7</a> <br /> <br />Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen | PNAS <br /><a href="https://www.pnas.org/doi/10.1073/pnas.1707304114" target="_blank" rel="nofollow">https://www.pnas.org/doi/10.1073/pnas.1707304114</a> <br /> <br /> <br />An mRNA Vaccine against SARS-CoV-2 — Preliminary Report | NEJM <br /><a href="https://www.nejm.org/doi/full/10.1056/NEJMoa2022483" target="_blank" rel="nofollow">https://www.nejm.org/doi/full/10.1056/NEJMoa2022483</a> <br /> <br />Structure-based design of prefusion-stabilized SARS-CoV-2 spikes - PMC <br /><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7402631/" target="_blank" rel="nofollow">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7402631/</a> <br /> <br />SARS-CoV-2 prefusion spike protein stabilized by six rather than two prolines is more potent for inducing antibodies that neutralize viral variants of concern | PNAS <br /><a href="https://www.pnas.org/doi/full/10.1073/pnas.2110105119" target="_blank" rel="nofollow">https://www.pnas.org/doi/full/10.1073/pnas.2110105119</a> <br /> <br />Frontiers | Enhancing the Prefusion Conformational Stability of SARS-CoV-2 Spike Protein Through Structure-Guided Design <br /><a href="https://www.frontiersin.org/articles/10.3389/fimmu.2021.660198/full" target="_blank" rel="nofollow">https://www.frontiersin.org/articles/10.3389/fimmu.2021.660198/full</a> <br /> <br />Closing coronavirus spike glycoproteins by structure-guided design - PMC <br /><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302216/" target="_blank" rel="nofollow">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302216/</a> <br /> <br />Prefusion Coronavirus Spike Proteins and Their Use | Technology Transfer <br /><a href="https://www.techtransfer.nih.gov/bundle/tab-3261" target="_blank" rel="nofollow">https://www.techtransfer.nih.gov/bundle/tab-3261</a> <br /> <br />Locking Down Shape-Shifting Spike Protein Aids Development of COVID-19 Vaccine - UT News <br /><a href="https://news.utexas.edu/2020/08/05/locking-down-shape-shifting-spike-protein-aids-development-of-covid-19-vaccine/" target="_blank" rel="nofollow">https://news.utexas.edu/2020/08/05/locking-down-shape-shifting-spike-protein-aids-development-of-covid-19-vaccine/</a> <br /> <br />SARS-CoV-2 S protein:ACE2 interaction reveals novel allosteric targets | eLife <br /><a href="https://elifesciences.org/articles/63646" target="_blank" rel="nofollow">https://elifesciences.org/articles/63646</a> <br /> <br />Epitope - Wikipedia <br /><a href="https://en.wikipedia.org/wiki/Epitope" target="_blank" rel="nofollow">https://en.wikipedia.org/wiki/Epitope</a><br />...<br /><a href="https://www.youtube.com/watch?v=XCmZSu1GrjY" target="_blank" rel="nofollow">https://www.youtube.com/watch?v=XCmZSu1GrjY</a>