cas: 10047-33-3 Gastrin I Human<br />CBNumber: CB5229406<br />Chemical Name: Gastrin I Human<br />Molecular Formula: C97H124N20O31S<br />Formula Weight: 2098.2<br />CAS No.: 10047-33-3<br />Gastrin I (human) is an endogenous peptide produced in the stomach that acts as a selective CCK2 receptor agonist. Gastrin I stimulates gastric acid secretion and has a mitogenic effect on gastric cells. Gastrin I stimulates gastric epithelial cell proliferation and histamine secretion (EC50 values are 6.2 pM and 0.014 nM, respectively). Gastrin I is also used in the culture of stomach, intestine and pancreas organoids. For more information about using Gastrin I in the generation of gastric organoids see the Human Gastric Organoid Culture Protocol.<br />Gastrins are a family of sequence-related carboxyamidated peptides produced by endocrine G cells of the antrum mucosa, and are potent stimulators of gastric acid secretion. Antral distension, partially digested proteins, amino acids, and vagal stimulation resulting from smelling, tasting, chewing or swallowing food all contribute to gastrin release from G cell storage. In addition, caffeine, alcohol, hypoglycemia, antacids and elevated calcium levels also stimulate gastrin release. Increased serum gastrin levels are associated with duodenal ulcers, Helicobacter pylori infections, colorectal carcinomas, and other tumors and cancerous lesions.