Nick talks to biochemist Jospeh Baur, PhD, whose lab at the University of Pennsylvania studies the molecular mechanisms of aging and metabolism. These discuss: aging as a passive vs. regulated process; mechanisms of aging (DNA mutations, oxidative stress, etc.); NAD and its role in normal physiology; the biology of sirtuins; rapamycin as an immunosuppressant & modulator of aging; the effects of diet & caloric restriction on aging; the potential slowing and reversing aging, and more.<br /><br />USEFUL LINKS<br />Sign up for the weekly Mind & Matter newsletter<br />[<a href="https://mindandmatter.substack.com/?s..." target="_blank" rel="nofollow">https://mindandmatter.substack.com/?s...</a>]<br /><br />Download the podcast & follow Nick at his website<br />[<a href="https://www.nickjikomes.com" target="_blank" rel="nofollow">https://www.nickjikomes.com</a>]<br /><br />Try Levels Health to monitor your blood sugar & optimize your diet<br />[<a href="https://www.levelshealth.com/join?par..." target="_blank" rel="nofollow">https://www.levelshealth.com/join?par...</a>]<br /><br />Follow Nick's work through Linktree:<br />[<a href="https://linktr.ee/trikomes" target="_blank" rel="nofollow">https://linktr.ee/trikomes</a>]<br /><br />Athletic Greens, comprehensive daily nutrition (Free 1-year supply Vitamin D w/ purchase)<br />[<a href="https://www.athleticgreens.com/mindan..." target="_blank" rel="nofollow">https://www.athleticgreens.com/mindan...</a>]<br /><br />Organize your digital highlights & notes w/ Readwise (2 months free w/ sub)<br />[<a href="https://readwise.io/nickjikomes/" target="_blank" rel="nofollow">https://readwise.io/nickjikomes/</a>]<br /><br />Learn more about our podcast sponsor, Dosist<br />[<a href="https://dosist.com" target="_blank" rel="nofollow">https://dosist.com</a>]<br /><br />0:00:00 Episode Intro<br />...<br /><a href="https://www.youtube.com/watch?v=ehbVXaKVMQk" target="_blank" rel="nofollow">https://www.youtube.com/watch?v=ehbVXaKVMQk</a>